Chondroitinase ABC Treatment and the Phenotype of Neural Progenitor Cells Isolated From Injured Rat Spinal Cord
نویسندگان
چکیده
منابع مشابه
Chondroitinase ABC treatment and the phenotype of neural progenitor cells isolated from injured rat spinal cord.
The aim of the present study was to investigate whether enzyme chondroitinase ABC (ChABC) treatment influences the phenotype of neural progenitor cells (NPCs) derived from injured rat spinal cord. Adult as well as fetal spinal cords contain a pool of endogenous neural progenitors cells, which play a key role in the neuroregenerative processes following spinal cord injury (SCI) and hold particul...
متن کاملP24: Neural Stem/Progenitor Cells Treatment for Spinal Cord Injury
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متن کاملChondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.
Chondroitin sulfate proteoglycans (CSPGs) are inhibitory extracellular matrix molecules that are upregulated after CNS injury. Degradation of CSPGs using the enzyme chondroitinase ABC (ChABC) can promote functional recovery after spinal cord injury. However, the mechanisms underlying this recovery are not clear. Here we investigated the effects of ChABC treatment on promoting plasticity within ...
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Background: Chondroitinase ABC (cABC), due to its loosening impact on the extracellular matrix scaffold, has been used to enhance regeneration of injured axonal tracts after spinal cord injury (SCI). However, cABC thermal instability at physiological temperature has limited its clinical application. The disaccharide trehalose has been shown to increase the stability of cABC in body temperature....
متن کاملp24: neural stem/progenitor cells treatment for spinal cord injury
spinal cord injury (sci) is a devastating condition, with sudden loss of sensory, motor, and autonomic function distal to the level of trauma. the primary mechanical trauma causes necrosis, edema, hemorrhage, and vasospasm. a cascade of secondary pathophysiological mechanisms is induced, including ischemia, apoptosis, fluid and electrolyte disturbances, excitotoxicity, lipid peroxidation, produ...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2011
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932125